This study investigated the antidepressant activity of ethanolic extract of U. lanosa Wallich var. appendiculata Ridsd (ULEtOH) for\r\ntwo-weeks administrations by using FST and TST on mice. In order to understand the probable mechanism of antidepressant-like\r\nactivity of ULEtOH in FST and TST, the researchers measured the levels of monoamines and monoamine oxidase activities in mice\r\nbrain, and combined the antidepressant drugs (fluoxetine, imipramine, maprotiline, clorgyline, bupropion and ketanserin). Lastly,\r\nthe researchers analyzed the content of RHY in the ULEtOH. The results showed that ULEtOH exhibited antidepressant-like activity in\r\nFST and TST in mice. ULEtOH increased the levels of 5-HT and 5-HIAA in cortex, striatum, hippocampus, and hypothalamus, the\r\nlevels of NE and MHPG in cortex and hippocampus, the level of NE in striatum, and the level of DOPAC in striatum. Two-week\r\ninjection of IMI, CLO, FLU and KET enhanced the antidepressant-like activity of ULEtOH. ULEtOH inhibited the activity of MAOA.\r\nThe amount of RHY in ULEtOH was 17.12 mg/g extract. Our findings support the view that ULEtOH exerts antidepressant-like\r\nactivity. The antidepressant-like mechanism of ULEtOH may be related to the increase in monoamines levels in the hippocampus,\r\ncortex, striatum, and hypothalamus of mice.
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